benzhydrocodone/acetaminophen and pentobarbital both of those raise sedation. Prevent or Use Alternate Drug. Limit use to patients for whom alternate cure possibilities are inadequate
Use in pregnancy: Barbiturates may cause fetal damage when administered to the pregnant woman. Retrospective, scenario-controlled experiments have proposed a connection concerning the maternal intake of barbiturates and a greater than predicted incidence of fetal abnormalities. Subsequent oral or parenteral administration, barbiturates conveniently cross the placental barrier and are distributed all over fetal tissues with greatest concentrations present in the placenta, fetal liver, and Mind.
pentobarbital will decrease the extent or influence of fostemsavir by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.
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Intramuscular Administration: IM injection of the sodium salts of barbiturates should be built deeply into a considerable muscle, and a here quantity of 5 mL really should not be exceeded at Anybody site as a consequence of achievable tissue discomfort.
pentobarbital will decrease the extent or influence of artemether/lumefantrine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration with solid CYP3A4 inducers can lead to lessened serum concentrations and loss of antimalarial efficacy
pentobarbital will reduce the extent or influence of guanfacine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Intently. Sturdy or moderate CYP3A4 inducers substantially lower guanfacine plasma concentrations and elimination fifty percent-lifetime.
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pentobarbital will lessen the level or influence of clarithromycin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Unknown.
pentobarbital will decrease the extent or influence of estrogens esterified by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
pentobarbital will lessen the level or impact of estrogens conjugated synthetic by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
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pentobarbital will lower the level or result of venetoclax by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
The sodium salt occurs as being a white, somewhat bitter powder that's freely soluble in drinking water and Liquor but pretty much insoluble in benzene and ether. Medical PHARMACOLOGY